Endocrine Abstracts

BackgroundRecent knowledge implicates a differential expression of the insulin-like growth factor-1 (IGF-1) mRNA splice variants (i.e., IGF-1Ea, IGF-1Eb and IGF-1Ec) in cancerous tissues, implying possible specific roles of the encoded IGF-1 protein isoforms in cancer biology. In particular, there is growing evidence that IGF-1Ec isoform may plays a distinct biological role in various types of cancer. The aim of the present study was to investigate wheth...

Background: Although papillary thyroid carcinoma (PTC) is considered to have an excellent prognosis, some more aggressive variants have been identified that show reduced overall survival rates. Besides from the diffuse sclerosing, tall cell, columnar cell, and solid variant, the hobnail variant was newly recognized as one of these aggressive forms, affecting recurrence, metastasis, and overall survival rates.Methods: We performed a systematic review and ...